Alternative first steps of purine biosynthesis.
نویسندگان
چکیده
18. SBARRA, A. J., AND KARNOVSKY, M. L., J. Biol. Chem., 235, 2224 (1960). ELSBACH, I?., J. Exptl. Med., 110, 969 (1959). BECKER, H., MUNDER, G., AND FISCHER, H., 2. Physiol. Chem., 313, 266 (1958). BECK, W. S., J: Biol. Chem., 232, 271 (1958). UMBREIT. W. W.. BURRIS. R. H., AND STAUFFER, J. F., Manometric iechnip&s, Ed. 3, Burgess Publishing co., Mmneapolis, 1957, p. 172. SCHWIND, J. L., Blood, 5, 597 (1950). Low, F. N., Electron-microscopic atlas of normal and leukemic h&an bldod, McGraw-Hill Book Co.,.Inc., New York, 1956. COHN. Z. A.. AND HIRSCH. J. G.. J. Exwtl. Med.. 112.983 (1960). McIL;AINE,‘T. C., J. B&Z. C&m., 491 183 (1921). ’ ’ ’ KAPLAN, N. O., COLOWICK, S. P., AND NEUFIELD, E. F., J. Biol. Chem., 205, 1 (1953). KORNBERG, A., in S. P. COLOWICK, AND N. 0. KAPLAN (Editors), Methods in enzymology, viol. I, Academic Press, Inc., New York, 1955, p. 441. FUTTERMAN, S., AND KINOSHITA, J. H., J. Biol. Chem., 234, 3174 (1959). HIRSCH, J. G., AND COHN, Z. A., J. Exptl. Med., 112, 1005 (1960). Rous, P., J. Exptl. Med., 41, 399 (1925). COHN, Z. A., AND HIRSCH, J. G., J. Exptl. Med., 112, 1015 (1960). DEDUVE, C., PRESSMAN, B. C., GIANETTO, R., WATTIAUX, R., AND APPLEMANS, F., Biochem. J., 60, 604 (1955). STRAUSS, W., J. Biophys. Biochem. Cytol., 5, 193 (1959).
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ورودعنوان ژورنال:
- The Journal of biological chemistry
دوره 236 شماره
صفحات -
تاریخ انتشار 1961